- Title
- Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial
- Creator
- do Rosario, Vinicius A.; Chang, Courtney; Williams, David; Wright, Ian M.R.; Charlton, Karen; Spencer, Jaclyn; Alahakone, Thilani; Roodenrys, Steven; Francois, Monique; Weston-Green, Katrina; Hölzel, Nadine; Nichols, David S.; Kent, Katherine
- Relation
- Clinical Nutrition Vol. 40, Issue 3, p. 879-889
- Publisher Link
- http://dx.doi.org/10.1016/j.clnu.2020.09.041
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2021
- Description
- Background & aims: Postprandial metabolic imbalances are important indicators of later developing cardiovascular disease (CVD). This study investigated the effects of food anthocyanins on vascular and microvascular function, and CVD associated biomarkers following a high fat high energy (HFHE) meal challenge in overweight older adults. Methods: Sixteen subjects (13 female, 3 male, mean age 65.9 SD 6.0 and body mass index 30.6 kg/m2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal. Results: Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine. Conclusion: Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD.
- Subject
- anthocyanins; flavonoid; postprandial; inflammation; endothelium; vascular; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1446320
- Identifier
- uon:42832
- Identifier
- ISSN:0261-5614
- Language
- eng
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